Jean-François Toussaint, Sanofi Pasteur lub taub hau ntawm kev tshawb fawb thiab kev loj hlob thoob ntiaj teb, ceeb toom tias qhov ua tiav ntawm cov tshuaj tiv thaiv mRNA tiv thaiv Covid tsis tau lees tias cov txiaj ntsig zoo sib xws rau tus mob khaub thuas.
"Peb yuav tsum txo hwj chim," nws hais."Cov ntaub ntawv yuav qhia peb yog tias nws ua haujlwm."
Tab sis qee qhov kev tshawb fawb qhia tias cov tshuaj tiv thaiv mRNA tuaj yeem ua pov thawj muaj zog dua li ib txwm muaj.Hauv kev tshawb fawb tsiaj, cov tshuaj tiv thaiv mRNA zoo li muab kev tiv thaiv dav dav tiv thaiv kab mob khaub thuas.Lawv ua rau tsiaj lub cev tiv thaiv kab mob los ua cov tshuaj tiv thaiv kab mob tiv thaiv kab mob, thiab tseem qhia cov kab mob tiv thaiv kab mob los tua cov kab mob.
Tab sis tej zaum tseem ceeb tshaj plaws rau tus mob khaub thuas, cov tshuaj tiv thaiv mRNA tuaj yeem ua tau sai.Kev nrawm ntawm mRNA kev tsim khoom tuaj yeem tso cai rau cov neeg tsim tshuaj tiv thaiv tos ob peb lub hlis ntxiv ua ntej xaiv cov kab mob khaub thuas siv, uas ua rau muaj kev sib tw zoo dua.
"Yog tias koj tuaj yeem lav 80 feem pua txhua xyoo, kuv xav tias qhov ntawd yuav yog txiaj ntsig kev noj qab haus huv rau pej xeem," said Dr. Philip Dormitzer, Pfizer tus thawj coj saib xyuas kev tshawb fawb.
Cov thev naus laus zis tseem ua rau nws yooj yim dua rau cov neeg siv tshuaj tiv thaiv mRNA los tsim kev txhaj tshuaj ua ke.Nrog rau mRNA molecules rau ntau hom kab mob khaub thuas, lawv tuaj yeem ntxiv mRNA molecules rau cov kab mob ua pa sib txawv.
Thaum lub Cuaj Hlis 9 kev nthuav qhia rau cov tub ua lag luam, Moderna tau qhia tawm cov txiaj ntsig los ntawm kev sim tshiab uas cov kws tshawb fawb tau muab cov tshuaj tiv thaiv nas sib xyaw ua ke mRNAs rau peb tus kab mob ua pa: mob khaub thuas raws caij nyoog, Covid-19 thiab ib hom kab mob hu ua pa syncytial virus, lossis RSV.Cov nas tau tsim cov tshuaj tiv thaiv kab mob siab rau tag nrho peb tus kab mob.
Lwm cov kws tshawb fawb tau tshawb nrhiav tshuaj tiv thaiv kab mob khaub thuas thoob ntiaj teb uas tuaj yeem tiv thaiv tib neeg tau ntau xyoo los ntawm kev tiv thaiv ntau yam kab mob khaub thuas.Tsis yog kev txhaj tshuaj txhua xyoo, tib neeg yuav xav tau kev txhawb nqa txhua ob peb xyoos.Hauv qhov xwm txheej zoo tshaj plaws, ib qho tshuaj tiv thaiv tuaj yeem ua haujlwm rau lub neej.
Hauv University of Pennsylvania, ib pab pawg kws tshawb fawb coj los ntawm Norbert Pardi tab tom tsim cov tshuaj tiv thaiv mRNA uas encode proteins los ntawm cov kab mob khaub thuas uas hloov pauv tsis tshua muaj.Cov kev sim hauv cov tsiaj pom tias cov tshuaj tiv thaiv no tuaj yeem siv tau los ntawm ib xyoos mus rau ib xyoos.
Txawm hais tias Moderna tsis ua haujlwm rau cov tshuaj tiv thaiv kab mob khaub thuas thoob ntiaj teb tam sim no, "nws yog ib yam dab tsi uas peb xav tau rau yav tom ntej," said Dr. Jacqueline Miller, lub tuam txhab tus thawj coj ntawm kev tshawb fawb kab mob sib kis.
Txawm hais tias cov tshuaj tiv thaiv kab mob khaub thuas mRNA nyob raws li qhov kev cia siab, lawv yuav xav tau ob peb xyoos kom tau txais kev pom zoo.Kev sim tshuaj tiv thaiv kab mob khaub thuas mRNA yuav tsis tau txais kev txhawb nqa tseem ceeb heev uas cov tshuaj tiv thaiv Covid-19 tau ua.Tsis yog cov tswj hwm yuav tso cai rau lawv kom tau txais kev tso cai xwm txheej ceev.Kev mob khaub thuas raws caij nyoog tsis yog ib qho kev hem thawj tshiab, thiab nws tuaj yeem raug tawm tsam nrog cov tshuaj tiv thaiv muaj ntawv tso cai.
Yog li cov tuam ntxhab yuav tau siv txoj hauv kev ntev dua kom pom zoo tag nrho.Yog tias qhov kev sim tshuaj thaum ntxov ua tau zoo, cov neeg tsim tshuaj tiv thaiv yuav tsum tau txav mus rau qhov kev sim loj loj uas yuav xav tau kom ncav cuag ntau lub caij khaub thuas.
"Nws yuav tsum ua haujlwm," said Dr. Bartley ntawm University of Connecticut."Tab sis pom tseeb tias yog vim li cas peb tshawb fawb - kom paub tseeb tias 'yuav tsum' thiab 'ua' yog tib yam."
Lub sij hawm xa tuaj: Plaub Hlis-21-2022